Peripheral blood DNA methylation as potential biomarker of Malignant Pleural Mesothelioma in asbestos-exposed subjects.

Journal of Thoracic Oncology 2018 November 5 [Link]

Guarrera S, Viberti C, Cugliari G, Allione A, Casalone E, Betti M, Ferrante D, Aspesi A, Casadio C, Grosso F, Libener R, Piccolini E, Mirabelli D, Dianzani I, Magnani C, Matullo G

Abstract

INTRODUCTION:
Malignant pleural mesothelioma (MPM) is an aggressive tumour strongly associated with asbestos exposure. Patients are usually diagnosed when current treatments have limited benefits, highlighting the need for non-invasive early diagnosis tests to monitor asbestos-exposed people.
METHODS:
We used a genome-wide methylation array to identify, in asbestos-exposed subjects, novel blood DNA methylation markers of MPM in 163 MPM cases and 137 cancer-free controls (82/68 Training Set; replication in 81/69, Test Set) sampled from the same areas.
RESULTS:
Evidence of differential methylation between MPM cases and controls was found (>800 CpG sites, Pfdr

source http://www.mesothelioma-line.com/2018/11/20/peripheral-blood-dna-methylation-as-potential-biomarker-of-malignant-pleural-mesothelioma-in-asbestos-exposed-subjects/