Friday, November 16, 2018

MUC21 Biomarker May Improve Mesothelioma Diagnosis Accuracy

A new study from Japan has shown that the protein mucin 21 (MUC21) can be used to help pathologists (doctors who study disease) distinguish between a mesothelioma diagnosis and adenocarcinoma diagnosis—a type of non-small cell lung cancer that accounts for roughly 40% of lung cancer cases and is a possible mesothelioma misdiagnosis. However, unlike other proteins

The post MUC21 Biomarker May Improve Mesothelioma Diagnosis Accuracy appeared first on Mesothelioma Help Now.



source http://www.mesotheliomahelpnow.com/blog/muc21-biomarker-may-improve-mesothelioma-diagnosis-accuracy/

Protein Found in Lung Fluid Could Be New Mesothelioma Predictor

Australian researchers have discovered a protein in lung fluid that could help them determine if a patient has mesothelioma months or potentially even years before the tumor has grown large enough to be visible in scans. Proteins as Mesothelioma Biomarkers Proteins are found naturally in the body. They are what different parts of our bodies

The post Protein Found in Lung Fluid Could Be New Mesothelioma Predictor appeared first on Mesothelioma Help Now.



source http://www.mesotheliomahelpnow.com/blog/protein-found-in-lung-fluid-could-be-new-mesothelioma-predictor/

Differential Survival characteristics of sarcomatoid subtype biphasic pleural mesothelioma.

Annals of Thoracic Surgery 2018 October 30 [Link]

Harling L, Kolokotroni SM, Nair A, Smelt J, King J, Routledge T, Spicer J, Ng W, Bille A

Abstract

BACKGROUND:
Biphasic mesothelioma (BPM) accounts for approximately 10% of all pleural mesothelioma. Our aim was to assess the clinical, radiological and pathological factors impacting survival in BPM and to better identify patients most likely to benefit from active treatment.
METHODS:
Ten-year retrospective review of 214 biopsy-proven BPM cases with minimum 2-year follow-up. Patients with insufficient tissue for analysis were excluded (n=96). Clinical and pathological factors were evaluated along with radiological assessment of pleural thickness. Survival was measured from time of diagnosis. Uni- and multi-variable predictors of survival were evaluated.
RESULTS:
118 patients were included. 28 underwent pleurectomy/decortication (P/D), with 27 receiving additional modalities. 90 underwent chemotherapy (n=18) or radiotherapy alone (n=9), 63 received combination therapy, and 27 received best supportive care (BSC). Median overall survival was 11.2 months (0.3-36.2). At univariable analysis, P/D (p=0.0061), radiotherapy (RT; p



source http://www.mesothelioma-line.com/2018/11/16/differential-survival-characteristics-of-sarcomatoid-subtype-biphasic-pleural-mesothelioma/

Hack Your Way to a Job in Legal Technology

hack job in legal technology post on lawyerist

A question more and more lawyers are asking these days is: How do I get a job in legal tech? It’s no surprise they’re asking it; legal tech is sexy and it beats the hell out of filing a request for documents for the millionth time.

Over the past year, I’ve done a deep dive into legal technology and I’ve found some proven paths for lawyers to find jobs in legal technology.

A note of warning: there aren’t as many jobs in legal tech as some lawyers hope. Most jobs at legal technology firms like LegalZoom or Clio are technology jobs, not legal jobs. Most of the opportunities in the legal tech space for lawyers come by way of entrepreneurship, which requires lawyers to carve their own path. These aren’t for the faint of heart.  

Also, I’m excluding obvious or more traditional jobs like working as a legal counsel for a legal technology company or serving as an attorney for an emerging technology company.

The following are key paths into the world of legal technology, coupled with illustrative, real-life examples.

Start a Dual-Entity Law Firm Integrated with Technology

Atrium has received a lot of press lately. It is a dual-entity law firm with both a business entity and a legal entity. This allows it to delegate the delivery of legal services and development of software to the business entity and the practice of law to the law entity.

Atrium isn’t alone in this space. Other startup law firms are providing similar services. Savvi Legal, for example, is a new dual-entity startup law firm founded by Dan Roberts. Dan worked in BigLaw for years as a venture attorney until he realized how repetitive legal work for startups can be. He created Savvi Legal to provide streamlined legal work to startups through automation and one-on-one counseling. And while it is too early to say, there may eventually be an opportunity to franchise with modern firms cut from this cloth.

Create Legal Technology for Your Big Law Firm

In 2017, Kimball Parker, a young attorney, contacted his local law school, BYU Law, and founded the LawX Legal Design Lab as an adjunct faculty. In its first year, LawX developed SoloSuit, an automated form generator that creates answers to complaints in debt collection lawsuits. Kimball then went on to create a similar technology, GDPR IQ, for his law firm Parsons Behle, automating GDPR documents during the 2018 GDPR rush.

Develop Technology Services for Other Lawyers

Filevine was born from the dissatisfaction of two attorneys: Ryan Anderson and Nathan Morris. Both litigation attorneys, they were frustrated with case management software available on the market, so they teamed with a software engineer and made their own. Now Filevine is a fast-growing CMS trying to carve out its niche aside giants like Clio.

Write on Legal Technology

Some lawyers have found their passion in writing about legal tech. The great Bob Ambrogi is the classic example, being both a lawyer and top legal technology journalist for decades. Dan Lear is another great example. He started his blog Right Brain Law, then found himself as the chief evangelist for one of the most successful legal technology companies ever, Avvo.

Start a Non-Profit

Not all legal tech innovation happens in businesses; nonprofits play an important part in innovation, too. Jameson Dempsey is a New York attorney who co-created the world-wide Legal Hackers network of Meetups. Legal Hackers began with the first-ever legal hackathon at Brooklyn Law School in 2012; today there are over 110 chapters around the world. Derek Parry founded Code 180, which turns legal professionals into novice computer programmers in 180 minutes. He started Code 180 while working as a corporate attorney and uses Code 180 to educate people in the legal industry on coding basics.

Some Other Assorted Ideas

The list doesn’t stop here. Really this is just the beginning of ways to break into legal technology. In all of these examples, the principle is the same: find a problem and solve it—preferably in a cool way that leverages the power of technology to solve sticky problems.

Here are some other assorted ideas.

  • Blockchain. Many blockchain companies are currently flush with cash, even during crypto-winter. Since many of the challenges blockchain companies face are inherently legal in nature, this is an easy sale for lawyers hoping to jump ship into a technology company.
  • Product management. Some select legal tech companies, like Fastcase, employee JDs in non-lawyer roles like product manager. This is a good place for “legal designers.”
  • Online attorney. Although this may not really be working in legal tech, some innovative attorneys will find what they are looking for in places like UpCounsel. UpCounsel calls itself the world’s largest law firm and allows its contracted attorneys to work from home and bid on cases online.  
  • Business development. Some B2L legal tech companies employ JDs in business development, using their credential to leverage connections with lawyers.

That’s the list for now. If you’ve got some other jobs to add to the list, please let me know in the comments below.  

The post Hack Your Way to a Job in Legal Technology appeared first on Lawyerist.com.

solosmalltech?d=yIl2AUoC8zA solosmalltech?d=qj6IDK7rITs


source https://lawyerist.com/hack-legal-tech-job/

Thursday, November 15, 2018

A Call for Global Asbestos Ban

Is this time to call for Global Asbestos Ban? So many реорlе still bеlіеvе asbestos is a thing of the раѕt. It wаѕ used in соnѕtruсtіоn аnd vаrіоuѕ рrоduсtѕ for centuries, аnd соuntlеѕѕ іndіvіduаlѕ believe now that іtѕ dangers аrе known, thе tоxіn has bееn bаnnеd. Sadly, thаt соuldn’t bе furthеr frоm the truth. Nоt оnlу is asbestos still bеіng used іn approximately 70% of thе wоrld, but ѕоmе countries still rely hеаvіlу on the іmроrt аnd еxроrt оf thе mineral.

Global Asbestos Ban

While the Unіtеd States thankfully doesn’t have a booming аѕbеѕtоѕ market these dауѕ, іt’ѕ still actively bеіng used in a fеw іnduѕtrіеѕ. Thе mіnеrаl іѕn’t banned аnd саn bе uѕеd іn сеrtаіn nеw рrоduсtѕ as lоng as іtѕ рrеѕеnсе іѕ оnlу up tо оnе реrсеnt. Along wіth these current uses, іt can still bе fоund in nаturаl deposits and thousands оf buіldіngѕ аnd hоmеѕ throughout thе соuntrу. If you or a loved one is showing stage four mesothelioma symptoms and are looking for stage four mesothelioma treatment options.

Mоrе соuntrіеѕ аrе joining the еffоrtѕ to rеасh a global asbestos ban аnd help eliminate thе health rіѕkѕ lіkе mеѕоthеlіоmа that аѕbеѕtоѕ саn саuѕе. Hоwеvеr, there іѕ ѕtіll a long wау to gо, еѕресіаllу in thе fасе of соuntrіеѕ lіkе Ruѕѕіа with a booming аѕbеѕtоѕ industry. An experienced New York mesothelioma lawyer or experienced Maryland mesothelioma lawyer can help anyone diagnosed with stage four mesothelioma.

Aѕbеѕtоѕ Use іn thе U.S.

Thоugh аѕbеѕtоѕ is nоwhеrе nеаr аѕ іmроrtаnt іn thе United States аѕ it once wаѕ, its ѕtіll асtіvеlу bеіng used. Many реорlе соnѕіdеr the main соnсеrn with asbestos tо bе its past, hіddеn in thе соnѕtruсtіоn оf оld buіldіngѕ thаt mаdе use оf a vаrіеtу оf аѕbеѕtоѕ рrоduсtѕ. Whіlе this legacy uѕеѕ аrе a grеаt threat tо thе public’s hеаlth, asbestos is ѕtіll bеіng іmроrtеd into the country fоr ѕеvеrаl uѕеѕ.

In Junе, the Environmental Prоtесtіоn Agеnсу (EPA) rеlеаѕеd a fіrѕt look іntо thеіr іnvеѕtіgаtіоn of thе first tеn chemicals bеіng evaluated fоr unreasonable rіѕk to рublіс аnd environmental hеаlth, іnсludіng аѕbеѕtоѕ. Thе EPA wаѕ gіvеn thе аuthоrіtу tо соnduсt rіѕk evaluations of ten chemicals and mоrе еасh уеаr аftеr thе ѕіgnіng оf the Frаnk R. Lаutеnbеrg Chеmісаl Sаfеtу fоr thе 21st Century Aсt іn 2016. Thоugh іt соuld still tаkе years tо potentially bаn аnу of these сhеmісаlѕ оn thе lіѕt, іt’ѕ a step іn thе rіght dіrесtіоn fоr a bаn.

In thіѕ іnіtіаl ѕсоріng document, wе learned thаt аbоut 340 mеtrіс tоnѕ (749,572 роundѕ) of rаw сhrуѕоtіlе asbestos hаd bееn imported іn 2016. The asbestos wаѕ іmроrtеd рrіmаrіlу frоm Brаzіl, whісh thе Unіtеd States Gеоlоgісаl Survеу (USGS) nоtеѕ hаѕ bееn thе main ѕоurсе fоr thе U.S. since 2012 as wеll. Hоwеvеr, the amount іmроrtеd has dropped ѕіgnіfісаntlу ѕіnсе thеn. In 2012, thе USGS еѕtіmаtеd аn import оf 1,610 tons, whісh decreased tо about 772 tons the fоllоwіng year. At іtѕ реаk uѕе back in 1973, thе Unіtеd Stаtеѕ соnѕumеd 803,000 tons оf аѕbеѕtоѕ. If you or a loved one was recently diagnosed with stage four mesothelioma or are showing early signs of stage four mesothelioma, contact the asbestos cancer organization.

Tоdау, thе іmроrtеd аѕbеѕtоѕ is рrіmаrіlу uѕеd for the chlor-alkali іnduѕtrу іn the сrеаtіоn оf ѕеmі-реrmеаblе dіарhrаgmѕ. Thе EPA also nоtеd a сurrеnt knоwn uѕе оf asbestos іn the сrеаtіоn of ѕhееt gаѕkеtѕ fоr thе сhеmісаl іnduѕtrу. Researchers аt the USGS, hоwеvеr, еxресt thе іnduѕtrу’ѕ аѕbеѕtоѕ uѕе to соntіnuе tо dесlіnе as mоrе соnѕumеrѕ ѕееk out non-asbestos dіарhrаgmѕ аnd рrоduсtѕ instead.

Is it time to call for Global Asbestos Ban?

Thе thоuѕаndѕ of tons of аѕbеѕtоѕ being consumed and рrоduсеd bу соuntrіеѕ across the globe, as wеll as thе іnсrеаѕіng wоrth оf thе trade, hіghlіghtѕ thе dіffісult rоаd ahead fоr еvеr moving a motion for global asbestos bаn. Asbestos is аn іmроrtаnt good fоr these and mаnу оthеr countries аrоund thе wоrld, аnd the market іѕ аlаrmіnglу grоwіng еасh уеаr.

Rеѕеаrсhеrѕ еѕtіmаtе аt lеаѕt 107,000 people dіе from asbestos-related diseases around thе world each уеаr. Anоthеr estimated 125 million реорlе аrе еxроѕеd tо аѕbеѕtоѕ аt work еасh уеаr аnd fасе the risk of thеѕе dеаdlу dіѕеаѕеѕ. Unfоrtunаtеlу, these dаngеrѕ аrе оvеrlооkеd оr ѕіmрlу unknown by so many people. Wіthоut a bаn, mаnу mоrе lives are аt ѕtаkе.

Despite the uphill battle, advocates around thе world аrе wоrkіng hаrd to make a dіffеrеnсе. Thankfully, thе numbеr оf countries bаnnіng thе tоxіn is slowly grоwіng, wіth соuntrіеѕ lіkе Cаnаdа and Tаіwаn еxресtеd to make a full ban bу 2020. Hореfullу with mоrе аwаrеnеѕѕ аnd thе соntіnuеd еffоrtѕ of thеѕе advocates аnd agencies, thе slow and ѕtеаdу progress for global asbestos ban wіll pick up the расе and рut an end tо this deadly іnduѕtrу. If you are searching for new mesothelioma treatment options, here at the asbestos cancer organization we can aide in your search.

Should asbestos be banned globally? let us know your view by making use of the comment box.

The post A Call for Global Asbestos Ban appeared first on The Asbestos Cancer Organization.



source https://asbestoscancer.org/global-asbestos-ban/

Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives.

Annals of Gastroenterology 2018 Nov-Dec [Link]

Boussios S, Moschetta M, Karathanasi A, Tsiouris AK, Kanellos FS, Tatsi K, Katsanos KH, Christodoulou DK

Abstract

Malignant peritoneal mesothelioma (MPM) is a rare disease with a wide clinical spectrum. It arises from the peritoneal lining and commonly presents with diffuse, extensive spread throughout the abdomen and, more rarely, metastatic spread beyond the abdominal cavity. Computed tomography, magnetic resonance imaging and positron-emission tomography are important diagnostic tools used for the preoperative staging of MPM. The definitive diagnosis is based on histopathological analysis, mainly via immunohistochemistry. In this regard, paired-box gene 8 negativity represents a useful diagnostic biomarker for differentiating MPM from ovarian carcinoma. In addition, BRCA1-associated protein-1 (BAP1) loss is specific to MPM and allows it to be distinguished from both benign mesothelial lesions and ovarian serous tumors. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has become an increasingly important therapeutic approach, while systemic therapies are still being developed. Histology, Ki-67, completeness of cytoreduction, age, sex, and baseline thrombocytosis are commonly used to optimize patient selection for CRS with HIPEC. Additionally, it is well recognized that, compared to other subtypes, an epithelial morphology is associated with a favorable prognosis, whereas baseline thrombocytosis predicts an aggressive biologicalbehavior. Platelets and other immunologic cytokines have been evaluated as potential novel therapeutic targets. Epigenetic modifiers, including BAP1, SETD2 and DDX3X, are crucial in mesothelial tumorigenesis and provide opportunities for targeted treatment. Overexpression of the closely interacting phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathways appears crucial in regulation of the malignant phenotype. The use of targeted therapies with PI3K-mTOR-based inhibitors requires further clinical assessment as a novel approach.



source http://www.mesothelioma-line.com/2018/11/15/malignant-peritoneal-mesothelioma-clinical-aspects-and-therapeutic-perspectives/

Untethered

untethered law firm job story being fired

“I’m sorry, I have to let you go.”

The head of the firm managed to look sad. I had started working for the firm less than a year before. I had been brought in at 60 years old because the firm wanted an older, experienced attorney to mentor the young guns in the firm.

I flatter myself in believing I had done this, sharing with the youngsters my trial experience, my voir dire questions, my knowledge of search and seizure case law, and my real-world understanding of what made clients tick.

“Can you tell me why?” I asked.

He shook his head.

“My lawyer told me not to say anything,” he said. The old dodge: Blame the lawyers.

“For what it’s worth,” he said, giving me a tiny sheepish smile, “I think you’re a good guy.”

I felt as if the floor underneath me had disappeared. I saw myself falling and falling and falling with no end in sight.

“I don’t like doing this,” the boss said. “You’re the first lawyer in ten years I’ve had to terminate.”

“Why does that not make me feel better?” I asked sickly.

I was 61 now. What the hell was I going to do?

My son would be getting married in two months. Fortunately, I had already purchased my airline tickets to the wedding in Indiana. The firm gave me enough in severance to get me through to then. But what would happen when I returned?

I half-jokingly told myself that maybe I would get lucky and the plane would crash on the way back. Financial problem solved.

I could look for another job, but I couldn’t indulge in the fantasy that I would find one. At my age, no one would seriously consider me, though they would all make a great show of doing so to avoid a discrimination claim.

Falling, falling, falling…

“What do you think I should do?” I said to my boss. He shook his head.

“Could you at least give me a recommendation letter?” I asked, grasping at the last tiny shred of dignity.

“My lawyer recommends we stay out of that,” he said.

When a lawyer loses a job, it’s different from when a real person loses a job. Most lawyers go through their lives with one or two firms, rarely facing the prospect of unemployment. To be fired would be an eternal black mark on my career.

I staggered out the door, boxes of my personal accouterment awkwardly in my hands. I was surprised there was still solid ground beneath my feet.

Two of my colleagues helped me get the boxes into the car and then stood outside with me telling me how much this sucked. I knew what they were thinking: What if this was me?

Finally, I drove off. I tried to pay attention to the road even though I was having an out of body experience.

I was untethered. It felt like my career was in my rear view mirror.

The post Untethered appeared first on Lawyerist.com.

solosmalltech?d=yIl2AUoC8zA solosmalltech?d=qj6IDK7rITs


source https://lawyerist.com/untethered/